Sergei Radchenko was born in Russia in 1988. While receiving an engineering degree from the Moscow University of Railway Transport as well as a public administration degree from the Russian Academy of National Economy and Public Administration, Sergey was introduced to classical singing at Moscow Popov Academy of Choral Art and the Moscow Tchaikovsky Conservatory.

Through 2011-2014, he gained significant musical, stage and language experience at the Bolshoi Theatre Young Artist Program, working with a lot of world known singers, conductors, directors, pianists and coaches. As a YAP member and later as a guest soloist of the Bolshoi Theatre, Sergey performed about 25 different roles, amongst which are the Prince (Rusalka by Dvorák), Grigory/Dimitry and the Simpleton (Boris Godunov), Lykov (The Tsar's Bride), Alfred and Eisenstein (Die Fledermaus), Don Juan (The Stone Guest), as well as cover of Hermann (Pique Dame).

In addition to his operatic performances at the Bolshoi, Sergey performed in a huge number of the YAP and Bolshoi projects, including tours in other cities and countries and chamber concerts with songs by Tchaikovsky, Rachmaninov, other Russian composers, French and German chamber music. He several times performed Schubert's Winterreise cycle.

Sergey's experience in other Russian theaters, besides everything mentioned above, further included Alfredo (La Traviata) and Don José (Carmen). Furthermore, he performed Hermann (Pique Dame) and Lensky (Eugene Onegin) in semi-stage versions at various venues, including Wiener Konzerthaus, the Moscow Zaryadye Concert Hall and the Tchaikovsky Concert Hall. He also performed Britten's Nocturne and Les Illuminations at various venues.

He made his Italian operatic debut in 2014 at the Teatro San Carlo di Napoli as Lensky (Eugene Onegin). Later, he performed Agrippa (Fiery Angel) at the Teatro dell’Opera di Roma, Chaplitsky (Pique Dame) at La Scala, Pinkerton (Madama Butterfly) and Turiddu (Cavalleria Rusticana) in Savona and Livorno, Alexei (The Gambler) at the Martina Franca Festival, Foresto (Attila) in Ancona, Lykov (The Tsar’s Bride) at Teatro Regio Torino.

In 2022, he sang Paul (Die tote Stadt) on tour with the Toluca Symphony Orchestra in Mexico. He was also invited for this role to the Moscow Novaya Opera Theatre.

In 2024, Sergey performed the male protagonist, heldentenor role of Mirko, in Augusta Holmès’s La Montagne Noire production at Dortmund Opernhaus. The production was nominated for International Opera Award 2024 in category “Best Rediscovery”.

In 2025, made his debut as Sergey (Serguei) in Shostakovich’s Lady Macbeth of Mtsensk at Palacio de Bellas Artes, Mexico City.

He repeatedly performed at Accademia Nazionale di Santa Cecilia in Rome – in Rachmaninov's The Bells, Scriabin's 1st Symphony and Tchaikovsky's Snow Maiden. He also performed Mahler's Das Lied von der Erde at the Teatro Comunale di Bologna and Moscow Tchaikovsky Concert Hall.

At Wiener Musikverein, Sergey’s stage appearance included Tchaikovsky’s unfinished opera Undina and Juan in Massenet’s Don Quichotte.

Amongst his concert experience is Mozart's Requiem, Beethoven's 9th Symphony, Rossini's Petite Messe Solennelle, Handel's Messiah, Haydn's Creation, Mendelssohn’s 2nd Symphony.

His discography includes a CD with a song cycle "Songs of the Palladin" by the contemporary Russian composer Georgy Dmitriev.